A Translation of Technology: MicroCoat™ to Sustained Release Orally Disintegrating Tablets

Orally disintegratingtablets (ODTs) comprising sustained release (SR) coated microparticles smallerthan 250 µm provide an appealing dosage form for patients with dysphagia,offering a superior mouthfeel and highly convenient route of administrationwithout the need water. SR coating requisite size(<200 µm) is incredibly challenging however utilisation theMicroCoat™ technology, whereby various dry powder glidants are added during SRcoating, was demonstrated to achieve desirable outcomes. ODTs were preparedvia direct compression. In addition conventional USP methods, texture analysis(TA) applied determine disintegration. shown disintegratewithin acceptable time (<30s) drug unaffected bycompression tabletting indicating robust coating.